Aggregation of cefprozil monohydrate

Aggregation behaviour of cefprozil monohydrate (C18H19N3O5S.H2O), an antibiotic, has been studied in presence of sodium dodecyl sulphate (SDS) and Cetyltrimethylammonium bromide (CTAB). Critical micelle concentration (CMC) of drug is determined to be 0.34 mM and is observed to decrease significantly at SDS < 2 mM. Above this concentration increase is less prominent and remains almost constant. However a regular decrease in CMC of Cepprozil monohydrate have been observed by increasing the concentration of CTAB. Variation in CMC values of SDS and CTAB have been studied at the premicellar region of Cefprozil monohydrate. A sharp decrease in the CMC of SDS and CTAB have been observed at low concentration of drug but at higher concentration variation in CMC of detergents is not significant. Effect of temperature on micellization of SDS and CTAB have been studied at 30o, 40o and 50oC with and without additive. Physicochemical parameters have been calculated utilizing pseudophaze model.